Biological Engineering (2015- Present)
PhD Research Scholar
My current research at IITGn focuses on understanding the molecular mechanisms of various small molecules and peptide modulators as aggregation inhibition which is the major cause of Parkinson’s disease. Parkinson’s disease (PD) is the 2nd most prevalent neurodegenerative disorder after Alzheimer’s disease which is accompanied by degeneration of neurons in substantia nigra. PD is a chronic and progressive movement disorder. Lewy bodies and Lewy neurites are pathological hallmarks of PD in which α-synuclein aggregation has been found to be a major event. α-Synuclein follows similar nucleation-dependent aggregation kinetics mechanism as found in other amyloidogenic proteins aggregation resulting in toxic species of oligomers and higher order aggregates such as fibrils. It has been proposed that the non-amyloidogenic component (NAC) region is the critical binding region in α-synuclein for it’s self-assembly in-vivo. My current research project is to stop the aggregation of α-Synuclein by synthesizing small molecules and peptides based on computational approach. These various small molecules modulators and short synthetic peptides can be screened and further selected.
In the long term, I want to foresee myself as a successful scientist to contribute my best of knowledge to the society for the betterment of humankind by collaborating with various industries.
Hometown: Jamnagar, Gujarat.
M.S.(Pharm): NIPER, S.A.S. Nagar, Mohali
B.Pharm: Nirma University, Ahmedabad
- Maqbool, M., Gadhavi, J., Singh, A., Hivare, P., Gupta, S., & Hoda, N. (2021). Unravelling the potency of triazole analogues for inhibiting α-synuclein fibrillogenesis and in vitro disaggregation. Organic & Biomolecular Chemistry, 19(7), 1589-1603. doi: 10.1039/d0ob02226h
- Maqbool, Mudasir, Joshna Gadhavi, Pravin Hivare, Sharad Gupta, and Nasimul Hoda. 2020. “Diphenyl Triazine Hybrids Inhibit Α-Synuclein Fibrillogenesis: Design, Synthesis And In Vitro Efficacy Studies”. European Journal Of Medicinal Chemistry 207: 112705. doi:10.1016/j.ejmech.2020.112705.